草榴社区

不对称催化方法学开发；药物的绿色合成方法开发

1. Jun-Long Li, Chuan Xie, Rong Zeng, Wen-Chao Yuan, Yuan-Yuan Lei, Ting Qi, Hai-Jun Leng, Qing-Zhu Li*, “Conditions-Controlled Divergent Annulation of Bicyclo[1.1.0]butanes and Dioxopyrrolidines through Lewis Acid Catalysis”, ACS Catal. 2025, 15, 6025–6035.
2. Qing-Zhu Li, Wen-Lin Zou, Zhao-Yuan Yu, Xin-Xin Kou, Yan-Qing Liu, Xiang Zhang, Yu He, Jun-Long Li*, “Remote site-selective arene C–H functionalization enabled by N-heterocyclic carbene organocatalysis”, Nat. Catal. 2024, 7, 900–911.
3. Qing-Zhu Li, Mei-Hao He, Rong Zeng, Yuan-Yuan Lei, Zhao-Yuan Yu, Min Jiang, Xiang Zhang, Jun-Long Li*, “Molecular Editing of Ketones through N-Heterocyclic Carbene and Photo Dual Catalysis”, J. Am. Chem. Soc. 2024, 146, 22829–22839.
4. Qing-Zhu Li, Rong Zeng, Peng-Shuai Xu, Xin-Hang Jin, Chuan Xie, Qi-Chuan Yang, Xiang Zhang, Jun-Long Li* “Direct Acylation of Unactivated Alkyl Halides with Aldehydes through N-Heterocyclic Carbene Organocatalysis”, Angew. Chem. Int. Ed. 2023, 62, e202309572.
5. Qing-Zhu Li, Yi-Long Guan, Qian-Wei Huang, Ting Qi, Peng Xiang, Xiang Zhang, Hai-Jun Leng, Jun-Long Li* “Temperature-Controlled Divergent Asymmetric Synthesis of Indole-Based Medium-Sized Heterocycles through Palladium Catalysis”, ACS Catal. 2023, 13, 1164–1172.
6. Qing-Zhu Li, Rong Zeng, Yang Fan, Yan-Qing Liu, Ting Qi, Xiang Zhang and Jun-Long Li*, “Remote C(sp3)−H Acylation of Amides and Cascade Cyclization via N-Heterocyclic Carbene Organocatalysis”, Angew. Chem. Int. Ed. 2022, 61, e202116629.
7. Qing-Zhu Li, Yan-Qing Liu, Xin-Xin Kou, Wen-Lin Zou, Ting Qi, Peng Xiang, Jin-Dun Xing, Xiang Zhang and Jun-Long Li*, “Oxidative Radical NHC Catalysis: Divergent Difunctionalization of Olefins through Intermolecular Hydrogen Atom Transfer”, Angew. Chem. Int. Ed. 2022, 61, e202207824.
8. Qing-Zhu Li, Xin-Xin Kou, Ting Qi, Jun-Long Li*, “Merging N-Heterocyclic Carbene Organocatalysis with Hydrogen Atom Transfer Strategy”, ChemCatChem 2023, 15, e202201320. (invited review).
9. Qing-Zhu Li, Wen-Lin Zou, Zhi-Qiang Jia, Jun-Long Li*, “Recent Advances on Annulation Reactions with Allyl and Propargyl Sulfonium Salts”, Synthesis 2022, 54, 67–78. (invited review).
10. Qing-Zhu Li, Zhi-Qiang Jia, Lin Chen, Xiang Zhang, Hai-Jun Leng, Rong Zeng, Yan-Qing Liu, Wen-Lin Zou, Jun-Long Li*, “Construction of a Benzo[b]azepine Skeleton through Decarboxylative Ylide [6+1] Annulations with Modified VinylBenzoxazinanones”, Org. Lett. 2021, 23, 814–818.
11. Hai-Jun Leng, Qing-Zhu Li*, Peng Xiang, Ting Qi, Qing-Song Dai, Zhi-Qiang Jia, Chuan Gou, Xiang Zhang, Jun-Long Li*, “Diastereoselective [3 + 1] Cyclization Reaction of Oxindolyl Azaoxyallyl Cations with Sulfur Ylides: Assembly of 3,3′-Spiro[β-lactam]-oxindoles” Org. Lett. 2021, 23, 1451–1456.
12. Qing-Zhu Li, Rong Zeng, Bo Han*, Jun-Long Li*, “Single-Electron Transfer Reactions Enabled by N-Heterocyclic Carbene Organocatalysis”, Chem. Eur. J. 2021, 27, 3238. (invited review).
13. Jun-Long Li, Yan-Qing Liu, Wen-Lin Zou, Rong Zeng, Xiang Zhang, Yue Liu, Bo Han,* Hai-Jun Leng, Qing-Zhu Li*, “Radical Acylfluoroalkylation of Olefins through N-Heterocyclic Carbene Organocatalysis”, Angew. Chem. Int. Ed. 2020, 59, 1863–1870. (IF: 16.823).
14. Qing-Zhu Li, Yue Liu, Me-Ze Li, Xiang Zhang, Ting Qi, Jun-Long Li*, “Palladium-catalysed decarboxylative annulations of vinylethylene carbonates leading to diverse functionalised heterocycles”, Org. Biomol. Chem. 2020, 18, 3638. (invited review).
15. Rong Zeng, Jun-Long Li*, Xiang Zhang, Yan-Qing Liu, Zhi-Qiang Jia, Hai-Jun Leng, Qian-Wei Huang, Yue Liu, Qing-Zhu Li*, “Diastereoselective Construction of 6,8-Dioxabicyclo[3.2.1]octane Frameworks from Vinylethylene Carbonates via Palladium-Organo Relay Catalysis”, ACS Catal., 2019, 9, 8256–8262.
16. Qing-Zhu Li, Xiang Zhang, Ke Xie, Qing-Song Dai, Rong Zeng, Yan-Qing Liu, Zhi-Qiang Jia, Xin Feng, Jun-Long Li*, “Diastereodivergent synthesis of cyclopropanes via on-water [2+1] annulations of diazo compounds with electron-deficient alkenes”, Green Chem., 2019, 21, 2375–2379.
17. Jun-Long Li, Qing-Song Dai, Kai-Chuan Yang, Yue Liu, Xiang Zhang, Hai-Jun Leng, Cheng Peng,* Wei Huang, Qing-Zhu Li* Org. Lett., 2018, 20, 7628–7632.
18. Qing-Zhu Li, Xiang Zhang, Rong Zeng, Qing-Song Dai, Yue Liu, Xu-Dong Shen, Hai-Jun Leng, Kai-Chuan Yang, Jun-Long Li*, “Direct Sulfide-Catalyzed Enantioselective Cyclopropanations of Electron-Deficient Dienes and Bromides”, Org. Lett., 2018, 20, 3700–3704.

纵向项目：
1.主持国家自然科学基金面上项目，22071011， 2020－2024。
2.主持国家自然科学基金青年项目，21702021, 2018－2020。
3.主持四川省科技厅应用基础项目，2021YJ0404, 2021－2023。
4.主持抗生素研究与再评价四川省重点实验室开放课题，2018-2020。
授权专利：
1. 一种苯并氮杂七元环化合物、其制备方法及用途。2022,中国专利202011477928.0 (第一发明人)
2. 一种具有多取代基的手性环丙烷化合物及其合成方法。2021,中国专利201711168516.7 (第一发明人)
3. 一种多取代手性烯基环丙烷化合物及其晶体和其制备方法与用途。2020,中国专利201711168515.2 (第一发明人)