草榴社区

不对称催化合成方法学研究；手性药物合成及其在抗感染药物发现中的应用

1. Chen. J.; Gong, X.; Li, J.; Li, Y.; Ma, J.; Hou, C.; Zhao, G.; Yuan, W.-C.*; Zhao, B.* Carbonyl catalysis enables a biomimetic asymmetric Mannich reaction. Science, 2018, 360, 1438.
2. You, Y.;* Yu, S.-L.; Li, Q.; Zhang, Y.-P.; Wang, Z.-H.; Zhao, J.-Q.; Yang, L.; Yuan, W.-C.* Progress in the Asymmetric Dearomatization Reactions of Arenols. ACS Catal. 2025, 15, 9503.
3. Lu, W.-Y.; You, Y.;* Wang, Z.-H.; Yang, L.; Zhao, J.-Q.; Zhou, M.-Q.; Yin, J.-Q.; Yuan, W.-C.* Dual-Copper-Catalyzed Enantioselective Decarboxylative [2 + 3] Cycloaddition of Ethynyl Cyclic Carbamates/Carbonates with 4-Hydroxycoumarins. Org. Lett. 2025, 27, DOI: 10.1021/acs.orglett.5c03409
4. Liu, J.-H.; Wang, J.-M.; Zhang, Y.-P.; Wang, Z.-H.; Zhao, J.-Q.; Zhou, M.-Q.;* You, Y.;* Yuan, W.-C.* Chiral Ag-Complex Catalyzed Enantioselective α-Functionalization of Cyclic Azomethine Ylides with Concomitant Remote-Controlled Asymmetric Desymmetrization of N-Arylmaleimides and Cyclopentene-1,3-diones. Chin. J. Chem. 2025, 43, 2029.
5. Dou, P.-H.; Fu, X.-H.; Chen, Y.; Ge. Z.-Z.; Zhou, M.-Q.; Wang, Z.-H.; You, Y.; Yang, L.; Zhang, Y.-P.; Zhao, J.-Q.;* Yuan, W.-C.* Palladium-Catalyzed Asymmetric Decarboxylation of 5‑Vinyloxazolidine-2,4-Diones Triggering the Dearomatization of Electron-Deficient Indoles for the Synthesis of Chiral Highly Functionalized Pyrroloindolines. Org. Lett. 2024, 26, 3310.
6. Fu, X.; Zhang. Y.; Liao, J.; Wang, Z.-H.; You, Y.; Zhou, M. Yuan, W.-C.* Palladium-catalyzed enantioselective decarboxylation of vinyl cyclic carbamates: Generation of amide-based aza-1,3-dipoles and application to asymmetric 1,3-dipolar cycloaddition. Chin. Chem. Lett. 2024, 35, 109688.
7. Shen. Y.-B.; Qian, H.-L.; Yang, L.; Zhou, S.; Rao, H.-W.; Wang, Z.-H.; You, Y.; Zhang, Y.-P.; Yin, J.-Q.; Zhao, J.-Q.;* Zhang, W.;* Yuan, W.-C.* Cu-Catalyzed Direct Asymmetric Mannich Reaction of 2-Alkylazaarenes and Isatin-Derived Ketimines, Org. Lett., 2024, 26, 1699.
8. Wang, Z.-H.;* Fu, X.-H.; Li, Q.; Zhao, J.-Q.; You, Y.; Zhang, Y.-P.; Yuan, W.-C.* Palladium-Catalyzed Ligand-Directed Divergent Decarboxylative Cycloadditions of Vinyloxazolidine-2,4-diones with 1,3,5-Triazinanes. Org. Lett., 2024, 26, 1589.
9. Zhuo, J.-R.; Zhao, J.-Q.;* Yang, L.; Wu, Y.-L.; Zhang, Y.-P.; You, Y.; Wang, Z.-H.; Zhou, M.-Q.; Yuan, W.-C.* Thiol-Triggered Tandem Dearomative Michael Addition/Intramolecular Henry Reaction of 2‑Nitrobenzofurans: Access to Sulfur-Containing Polyheterocyclic Compounds. Org. Lett., 2024, 26, 2623.
10. Wang, Z.-H.;* Huang, D.-Q.; Wang, P.; Yang, L.; You, Y.; Zhao, J.-Q.; Zhang, Y.-P.; Yuan, W.-C.* Synthesis of 6/5/3-Fused Tricyclic Scaffolds via Multistep Cascade Cyclization of α‑Aryl Vinylsulfoniums with para-Quinamines and para-Quinols. Org. Lett., 2024, 26, 5905.

科研项目：
1. 国家自然科学基金面上项目，2022.01-2025.12，主持
2.国家自然科学基金面上项目，2019.01–2022.12
3. 国家自然科学基金面上项目，2016.01–2019-12，主持
4. 国家自然科学基金面上项目，2014.01–2017.12
5. 国家自然科学基金青年科学基金，2009.01–2011.12，主持
6. 重要化学毒物及氘代物标准物质的研制，“十三五”国家重点研发项目子课题，2018.07–2021.06，主持
7. 四川省杰出青年基金，2013.01-2015.12，主持
8. 四川省自然科学基金面上项目， 2024.01-2025.12，主持
9. 四川省顶尖创新团队，2016.01–2018.12，主持
10. 四川省青年科技创新团队，2016.01–2018.12，主持
11. 成都市顶尖创新团队，2015.01–2017.12，主持
12. 草榴社区 人才工程科研启动项目，2019.5–2024.12，主持
授权专利：
申请中国发明专利45件，授权中国发明专利36件，授权国际专利1件。
专著:
1.《Spirooxindole—Chemistry, Synthesis, Characterization and Biological Significance》, Published by Elsevier：2024, Chapter 3.
2. 《Recent Advances in Organocatalysis》, Published by InTech：2016, Chapter 3.