草榴社区

药物新制剂及新技术研究、靶向纳米递药系统

1.Ling Mei, Man Li, Qin He. Self-propelled smart nanomotors for enhanced mild photothermal therapy of tumors through autophagy modulation. Acta Biomater. 2025, S1742-7061(25)389-7.
2.Qihang Ding, Haowei Liu, Lishan Yan, Liang Chen, Yu Chen, Jong Seung Kim, Ling Mei*. 《Engineering a Multifunctional Nanozyme Platform for Synergistic Melanoma Therapy: Integrating Enzyme Activity, Immune Activation, and Low-Temperature Photothermal Effects. Angew. Chem. Int. Ed. 2025: e202505911.
3.Qihang Ding, Siqi Huang, Zihan Zhang, Donghu Yu, Man Li, Qin He, Ling Mei*. Integration of Photodiagnosis and Therapy Guided by Micro/Nanorobots. Adv Mater. 2025, 37(18): e2420359.
4.Qihang Ding, Haiyan Chen, Yifan Zhang, Junbin Yang, Man Li*, Qin He*, Ling Mei*. Innovative integration of nanomedicines and phototherapy to modulate autophagy for enhanced tumor eradication. J Control Release. 2025(377): 855-879.
5.Ling Mei, Qihang Ding, Yuxin Xie, Haowei Liu, Hongping Li, Eunji Kim, Xue Shen, Yibin Zhang*, Shuai Zhang*, Jong Seung Kim*. Self-propelling intelligent nanomotor: A dual-action photothermal and starvation strategy for targeted deep tumor destruction. Biomaterials. 2025(315), 122968.
6.Ling Mei, Yifan Zhang, Kaixi Wang, Sijing Chen, Tao Song*. Nanomaterials at the forefront of antimicrobial therapy by photodynamic and photothermal strategies. Mater. Today Bio, 2024(29),101354.
7.Na Tu, Xue Shen, Shengqi Deng, Yuxin Xie, Haowei Liu, Hongping Li, Nan Li*, Ling Mei*. Antitumor and immunotherapy sensitizing effects of a thermosensitive liposome by increasing autophagosome accumulation. ACS Appl. Nano Mater, 2023, 6, 24, 23150–23162.
8.Ling Mei, Minzhi Yu, Yayuan Liu, Eric Weh, Mercy Pawar, Li Li, Cagri G Besirli, Anna A Schwendeman*. Synthetic high-density lipoprotein nanoparticles delivering rapamycin for the treatment of age-related macular degeneration. Nanomed-Nanotechnology, 2022 (44), 102571.
9.Ling Mei, Jingdong Rao, Yayuan Liu, Man Li, Zhirong Zhang, Qin He*. Effective treatment of the primary tumor and lymph node metastasis by polymeric micelles with variable particle sizes. J Control Release, 2018 (292):67-77.
10.Ling Mei, Yayuan Liu, Jingdong Rao, Xian Tang, Man Li, Zhirong Zhang, Qin He*. Enhanced tumor retention effect by click chemistry for improved cancer immunochemotherapy. ACS Appl. Mater Inter, 2018, 10(21):17582-17593.
11. Ling Mei, Yayuan Liu, HuaJin Zhang, Zhirong Zhang, Huile Gao, Qin He*. Antitumor and antimetastasis activities of heparin-based micelle served as both carrier and drug. ACS Appl. Mater Inter, 2016, 8(15):9577-9589.
12. Ling Mei, Yayuan Liu, Qianyu Zhang, Huile Gao, Zhirong Zhang, Qin He*. Enhanced antitumor and anti-metastasis efficiency via combined treatment with CXCR4 antagonist and liposomal doxorubicin. J Control Release, 2014 (196):324-331.

主持：
新型水凝胶用于糖尿病感染的开发研究 2025.8-2027.8
藤黄酸脂质体的制备及抗病毒评价 2024.7-2025.7
核酸递送脂质纳米粒小鼠体内转染研究 2023.5-2025.4
联合开展2022年眉山市科技局科研项目 纳米粒调控自噬增强化疗诱导的抗肿瘤免疫应答在三阴性乳腺癌治疗中的应用 2022.8-2023.7
美国心脏协会博士后项目 Synthetic high-density lipoprotein mediated delivery of bioactive lipids for the treatment of cardiovascular disease. 2020.1-2021.12
参与：
国家自然科学基金
高效原位瘤及淋巴转移瘤靶向的可变粒径纳米递药系统的研究，2018.1-2021.12
基于粒径智能化调控及程序性释放自噬抑制剂和化疗药物的纳米传递系统的构建及评价，2016.1- 2019.12
基于"一头多效"靶头高效跨越肿瘤递药屏障的脂质体给药系统的构建及评价，2014.1-2017.12