草榴社区

主要从事微环境响应性智能化多功能纳米载药体系用于靶向制剂、分子成像、和诊疗一体化的相关研究，并致力于细胞-纳米药物交互作用与力学调控机制等交叉学科研究。

1. Qihang Ding#, Wenhao Li#, Ling Mei, Suling Luo, Jing Tao, Chongxiu Shi, Hongping Yang, Wei Feng, Yungchang Chen*, Yu Chen*, Jong Seung Kim*, Xue Shen*. Tailoring Advanced Metal-Based Nanomedicines for Adaptable Nanodynamic Disease Therapies and Theranostics. Advanced Materials, 2025, e13609 (中科院1区Top，IF=26.8)
2. Qihang Ding#, Chongxiu Shi#, Hao Wu#, Yin Chen, Wenhao Li, Hongping Yang, Liming Zhu, Li Ye, Yongqi Peng, Ling Mei, Tao Song, Yungchang Chen*, Yiyao Liu*, Xue Shen*. Selenium-derived bioactive enablers for advanced therapies: From molecular redox modulation to broad-spectrum disease applications. Bioactive Materials, 2026, 57, 182-230 (中科院1区Top，IF=20.3)
3.Hao Wu#, Hongping Li#, Li Li#, Yungchang Chen, Hongping Yang, Chongxiu Shi, Wenhao Li, Li Ye, Liming Zhu, Gang He, Suling Luo, Jing Tao*, Ling Mei*, Xue Shen*. Microenvironment-responsive size-adaptive nanoparticles: hyaluronidase/acid/NIR light activation for deep-penetration trimodal therapy. Materials Today Bio, 2025, 35, 102384 (中科院1区Top，IF=10.2)
4. Qihang Ding#, Yi Luo#, Hao Wu, Jing Tao, Yibin Zhang, Gang Yin, Kun Qian, Yungchang Chen, Ling Mei*, Zhen Cheng*, Xue Shen*. PLGA nanomedicine for inflammatory bowel disease: targeted delivery and integrated diagnostics toward precision treatment. Science China Chemistry, 2025, 68 (11): 5451-5482 (中科院1区Top，IF=9.8)
5. Yin Chen#, Xue Shen#, Songling Han, Tao Wang, Jianqi Zhao, Yongwu He, Shilei Chen, Shengqi Deng, Cheng Wang*, Junping Wang*. Irradiation pretreatment enhances the therapeutic efficacy of platelet-membrane-camouflaged antitumor nanoparticles. Journal of Nanobiotechnology, 2020, 18:101 (中科院1区Top，IF=12.6)
6. Xue Shen, Xiyang Liu, Tingting Li, Yin Chen, Yang Chen, Pan Wang, Lin Zheng, Hong Yang, Chunhui Wu, Shengqi Deng*, Yiyao Liu*. Recent Advancements in Serum Albumin-Based Nanovehicles Toward Potential Cancer Diagnosis and Therapy. Frontiers in Chemistry, 2021, 9: 746646
7. Xue Shen, Tingting Li, Xiaoxue Xie, Yi Feng, Zhongyuan Chen, Hong Yang, Chunhui Wu, Shengqi Deng*, Yiyao Liu*. PLGA-based drug delivery systems for remotely triggered cancer therapeutic and diagnostic applications. Frontiers in Bioengineering and Biotechnology, 2020, 8: 381
8. Xue Shen, Tingting Li, Zhongyuan Chen, Xiaoxue Xie, Hanxi Zhang, Yi Feng, Shun Li, Xiang Qin, Hong Yang, Chunhui Wu, Chuan Zheng, Jie Zhu, Fengming You, Yiyao Liu*. NIR light-triggered anticancer strategy for dual-modality imaging-guided combination therapy via a bioinspired hybrid PLGA nanoplatform. Molecular Pharmaceutics, 2019, 16(3): 1367-1384
9. Xue Shen, Tingting Li, Zhongyuan Chen, Yue Geng, Xiaoxue Xie, Shun Li, Hong Yang, Chunhui Wu, Yiyao Liu*. Luminescent/magnetic PLGA-based hybrid nanocomposites: a smart nanocarrier system for targeted codelivery and dual-modality imaging in cancer theranostics. International Journal of Nanomedicine, 2017, 12: 4299-4322
10. Yong Huang#, Xue Shen#, Haixia Qiao, Hao Yang, Xuejiao Zhang, Yiyao Liu*, Hejie Yang*. Biofunctional Sr- and Si-loaded titania nanotube coating of Ti surfaces by anodization-hydrothermal process. International Journal of Nanomedicine, 2018, 13: 633-640
11. Na Tu, Xue Shen, Shengqi Deng, Yuxin Xie, Haowei Liu, Hongping Li, Nan Li*, Ling Mei*. Antitumor and immunotherapy sensitizing effects of a thermosensitive liposome by increasing autophagosome accumulation. ACS Applied Nano Materials, 2023, 6(24): 23150-23162
12. Tingting Li, Xue Shen, Yue Geng, Zhongyuan Chen, Li Li, Shun Li, Hong Yang, Chunhui Wu, Hongjuan Zeng, Yiyao Liu*. Folate Functionalized Magnetic-mesoporous silica nanoparticles for drug/gene codelivery to potentiate the antitumor efficacy. ACS Applied Materials & Interfaces, 2016, 8(22): 13748-13758
13. Tingting Li, Xue Shen, Yin Chen, Chengchen Zhang, Jie Yan, Hong Yang, Chunhui Wu, Hongjuan Zeng, Yiyao Liu*. Polyetherimidegrafted Fe3O4@SiO2 nanoparticles as theranostic agents for simultaneous VEGF siRNA delivery and magnetic resonance cell imaging. International Journal of Nanomedicine, 2015, 10: 4279-4291
14. Tingting Li, Xue Shen, Xiaoxue Xie, Zhongyuan Chen, Shun Li, Xiang Qin, Hong Yang, Chunhui Wu, Yiyao Liu*. Irinotecan/IR-820 co-loaded hollow mesoporous silica nanoparticles as a platform for combinational chemotherapy and photothermal therapy of tumor. Nanomedicine, 2018, 13(6): 595-603
15. Hong Yang, Xue Shen, Jie Yan, Xiaoxue Xie, Zhongyuan Chen, Tingting Li, Shun Li, Xiang Qin, Chunhui Wu, Yiyao Liu*. Charge-reversal-functionalized PLGA nanobubbles as theranostic agents for ultrasonic-imaging-guided combination therapy. Biomaterials Science, 2018, 6: 2426-2439
16. Xiaohong He, Xue Shen, Dongming Li, Yiyao Liu, Kun Jia*, Xiaobo Liu*. Dual-mode fluorescence and magnetic resonance imaging nanoprobe based on aromatic amphiphilic copolymer encapsulated CdSe@CdS and Fe3O4. ACS Applied Bio Materials, 2018, 1(2): 520-528
参编出版高等院校“十四五”创新教材:
1.《中医药与前沿科学技术导论》，人民卫生出版社，标准书号：ISBN 978-7-117-37295-4，2025

承担及主研多项省部级科研平台开放科研课题，主持多项国家及省部级科研平台开放课题，作为主研人员参与多项国家自然科学基金项目，指导学生获得多项省级创新创业项目立项。 主持科研项目：
1. 硒纳米药物联合anti-PD-L1用于肿瘤化学-光热-免疫治疗研究，2024.07-2026.07
2. 靶向恶性脑胶质瘤的功能化纳米脂质体的构建及其抗肿瘤策略研究，2022.01.01-2022.12.30
3. 级联靶向脑胶质瘤的工程化血小板膜仿生纳米诊疗体系的构建及其光热免疫治疗策略研究，2021.12.01-2022.12.01
参与国家自然科学基金项目：
1. 基于光遗传学技术研究细胞骨架网络对肿瘤细胞群体迁移的调控作用与生物力学机制，青年科学基金项目，2019-01-01 至 2021-12-31
2. 功能图案化EQCM生物传感器用于乳腺癌微转移能力和标志物检测的研究，面上项目，2018-01-01 至 2021-12-31
3. 三维基质粘弹性影响乳腺癌细胞凋亡和自噬交互作用的力学生物学机制研究，面上项目，2018-01-01 至 2021-12-31
4. 发光/磁性杂合靶向纳米胶束联合阿霉素和miR-34a治疗肿瘤协同增敏和双模态成像研究，面上项目，2017-01-01 至 2020-12-31