草榴社区

1. 新型抗炎药物的研发及其在治疗非可控性炎性疾病中的探索
2. 计算机辅助药物设计发现苗头化合物
3. 体内药物分析

1.Yang, Fan＃; Dai, Zhen＃.; Xue, Mingyu＃..; Chen, Xiaoyi.; Liu, J.; Wang, Li.; Xu, Lili;* Di, Bin* Identification and validation of pkr as a direct target for the novel sulfonamide-substituted tetrahydroquinoline nonselective inhibitor of the nlrp3 inflammasome. J. Med. Chem. 2024, 67, 10168-10189. (中科院一区TOP, 共同第一作者)
2.Dai, Zhen＃.; An, Luyan＃; Chen, Xiaoyi＃.; Yang, Fan.; Zhao, Ni.; Li, Cuicui.; Ren, Ren.; Li, B. Y.; Tao, W. Y.; Li, Pei.; Jiang, Cheng.; Yan, Fan.; Jiang, Zhengyu.; You, Qidong.; Di, Bin.; Xu, Li.- Li.. Target fishing reveals a novel mechanism of 1,2,4-oxadiazole derivatives targeting rpn6, a subunit of 26s proteasome. J. Med. Chem. 2022, 65, 5029-5043. (中科院一区TOP, 共同第一作者)
3.Dai Zhen; Chen Xiao-Yi; An Lu-Yan; Li Cui-Cui; Zhao Ni; Yang Fan; You Song-Tao; Hou Chen-Zhi; Li Kan; Jiang Cheng; You Qi-dong; Di Bin; Xu Li-Li; Development of Novel Tetrahydroquinoline Inhibitors of NLRP3 Inflammasome for Potential Treatment of DSS-Induced Mouse Colitis, J. Med. Chem, 2021, 64(1): 871-889. (中科院一区TOP,第一作者)
4.Dai, Zhen*.; Wang, Ke.; Bai, Chenli. Li, Yong*.; Yu, Quanwei.; Chen, Zhiping.; Liao, Jihong.; Ding, Jianjun.; Wang, Yuxi*. Discovery of a novel thiazole amide inhibitor of inflammasome and pyroptosis pathways., Bioorg. Chem. 2025, 160, 108477. (中科院二区,第一作者，共同通讯作者)
5.Dai, Zhen; Yang, Donglin; Wang, Ke; Chen, Zhiping; Tan, Jihong; Tian, Yue; Tang, DianYong; Xu, Zhigang; Chen, Zhongzhu; Li, Yong; Multicomponent reaction synthesis and evaluation of novel 3,4-dihydropyrazine[1,2-b]Indazole-1(2H)-one derivatives as inhibitors of pyroptosis and inflammation, Molecular Diversity, 2025, (中科院二区,第一作者)
6.Dai Zhen*; Liu Wangcong; Chen Xiaoyi; Wang Xiao; , et al. Gasdermin D-mediated pyroptosis: mechanisms, diseases, and inhibitors. Front. Immunol. 2023;14:1178662. (中科院二区,第一作者，共同通讯作者)
7.Lili Xu, Yufeng Wu, Fang Yan, Cuicui Li, Zhen Dai, Qidong You*, Zhengyu Jiang*, Bin Di*.5-(3,4-Difluorophenyl)-3-(6-methylpyridin-3-yl)-1,2,4-oxadiazole (DDO-7263), a novel Nrf2 activator targeting brain tissue, protects against MPTP-induced subacute Parkinson's disease in mice by inhibiting the NLRP3 inflammasome and protects PC12 cells against oxidative stress, Free Radical Biology and Medicine, 2019, 134, 288–303.
8.Lili Xu, Cuicui Li, Luyan An, Zhen Dai, Xiaoyi Chen, Qidong You*, Chi Hu*, Bin Di*. Selective apoptosis-inducing activity of synthetic hydrocarbon-stapled SOS1 helix with D-amino acids in H358 cancer cells expressing KRASG12C, European Journal of Medicinal Chemistry, 2020, 185, 111844.
9.Qiwei Wang*, Zhen Dai, Xiangjie Di, QingFei Huang*, Yuanhua Wang*, Jin Zhu, Pd(NHC)(cinnamyl)Cl‑catalyzed Suzuki cross‑coupling reaction of aryl sulfonates with arylboronic acids，Molecular Diversity, 2020, 24, 903–911.
10.代祯，王亚鹏，赵慧慧等，氮杂环卡宾-铁配合物催化碳-碳偶联反应的研究进展，合成化学，2024，32，05，469-484.

纵向项目：
1. 主持国家自然科学基金青年项目82204220， 2023－2025。
2. 主持四川省自然科学基金青年项目2023NSFSC1689, 2023－2024。
授权专利：
1. 一种母核为四氢喹啉的磺酰胺类化合物及其制备方法和应用, 中国发明专利，专利公开号: CN 110078663 A
2. DB-1在制备防治NLRP3炎症小体相关疾病的药物中的应用及其药物组合物，中国发明专利，专利公开号: CN 111494380 A
3. 一种母核为吡唑并[3 ,4-d]嘧啶类化合物及其制备方法, 中国发明专利，专利公开号: CN 110734439 A