草榴社区

师资队伍

李喆宇

职称:副研究员

最高学历毕业院校及专业:成都中医药大学草榴社区 中药化学

所属学科:药物分析

电子邮件:[email protected]

个人简历

研究方向

代表性论著

教学科研项目及获奖

职称 副研究员 最高学历毕业院校及专业 成都中医药大学草榴社区 中药化学
所属学科 药物分析 电子邮箱 [email protected]
研究方向 基于质量控制的中药活性成分防霉养护技术研发与机制解析、过渡金属催化策略在抗菌药物研发中的应用与效能优化研究。 发表论文 在国内外知名期刊上发表中英文论文38篇,其中中科院TOP期刊论文4篇、二区论文4篇。<br>
1.Zheyu Li, Wenbo Ma, Linghui Gu, Jiayuan Xie, Kui Yang & Shibo Lin. Recent developments in the utilization of pyridones as privileged scaffolds in drug discovery, 20(7), 873–889. (中科院二区,一作)<br>
2.Li B, Zhou Y, Xu Yue, Li Xiang, Li Zheyu, Gu Linghui, Ma Wenbo, Mei Ruhuai. Transition-Metal-Free Electrochemical Selenylative Cyclization of Alkynyl Phosphonates.The Journal of Organic Chemistry, 2023, 88(21):15414-15427. (中科院二区,通讯作者)<br>
3.Jiajun Hu, Bo Li, Feng Xiong, Yue Xu, Zheyu Li, Linghui Gu. Electrochemically Driven Chalcogenative Cyclization of 2Alkynyl Aryl Oxime: Access to Functionalized Isoquinolines. The Journal of Organic Chemistry (中科院二区)<br>
4.Li, B. ,  Zhou, Y. ,  Xu, Y. ,  Li, X. ,  Li, Z. , &  Gu, L. , et al. (2023). Transition-metal-free electrochemical selenylative cyclization of alkynyl phosphonates. The Journal of Organic Chemistry, (21), 88. (中科院二区)<br>
5.Tao Zheng, Zihan Yu, Junlong Li, Qilin Gu, Linghui Gu, Zheyu Li,* and Wenbo Ma*. Solvent-Free Dehydrogenative C-H Chalcogenations of Pyrazolones Using Mechanochemistry.Asian Journal Of Organic Chemistry,2024. (中科院四区,通讯作者)<br>
6. Li, Zheyu#,*; Sun, Yanan#; Gu, Linghui; Wang, Yuchi; Xu, Mingqin; Zhou, Yunhao; Hu, Yichen*; Ma, Wenbo*. Ar-turmerone suppresses Aspergillus flavus growth and aflatoxin accumulation: Finding a new antifungal agent based on stored maize. Food Research International. 2023, 168: 112735. (中科院一区,TOP期刊,一作)<br>
7. Gong, Xin; Yu, Na; Gu, Linghui; Li, Zheyu*; Ma, Wenbo*; Zhao, Fei*. Redox-neutral rhodium(iii)-catalyzed divergent synthesis of tetrasubstituted 1,3-enynes and alkynylated benzofurans. Organic & biomolecular chemistry, 2023, 21(1): 147-152. (中科院三区,通讯作者)<br>
8. Li, Zheyu; Yang, Chen; Li, Zhiyi; Sun, Yanan; Lin, Shibo*; Hu, Yichen*. Application and safety evaluation of an anti-aflatoxigenic chitosan pouch containing turmeric essential oil in the storage of traditional Chinese health food. International Journal of Biological Macromolecules, 2021, 183(1): 1948-1958. (中科院二区,TOP期刊,一作)<br>
9. Li, Zheyu; Lin, Shibo; An, Siyi; Liu, Lu; Hu, Yichen*; Wan, Li*. Preparation, characterization and anti-aflatoxigenic activity of chitosan packaging films incorporated with turmeric essential oil. International Journal of Biological Macromolecules, 2019, 131: 420-434. (中科院二区,TOP期刊,一作)<br>
10. Lin Shibo, Liu Chun, Zhao Xiaotian, Han Xiao, Li Xuanhao, Ye Yongqin, Li Zheyu. Recent Advances of Pyridinone in Medicinal Chemistry. Frontiers in Chemistry. 2022, 10 (中科院三区)<br>
11. Yu, Yao; Wang, Yang; Li, Bo; Tan, Yuqiang; Zhao, Huan; Li, Zheyu*; Zhang, Chunran*; Ma, Wenbo*. Ruthenium-Catalyzed Vinylene Carbonate Annulation by C-H/N-H Functionalizations: Step-Economical Access to Indoles. Advanced Synthesis & Catalysis, 2022, 364(4): 838-844. (中科院二区,通讯作者)<br>
12. Liu, Changying#; Li, Zheyu#; Weng, Zhengyun; Fang, Xinyue; Zhao, Fei; Tang, Kehui*; Chen, Jianyang*; Ma, Wenbo*. Transition-Metal-Free Selective C(sp(3))-H Thiolation of Arylacetamides with Substituted Benzenethiols, Aryl Sulfenylchlorides and Diaryl Disulfides. Asian Journal of Organic Chemistry, 2020, 9(4): 668-672. (中科院三区,共同一作)<br>
13. Zhang, Jing-Xia; Li, Zhe-Yu; Wang, Yu-Chi; Ma, Wen-Bo; Hou, Ming; Cao, Sheng-Hua; Tang, Ke-Hui; Dong, Hong-Bo*. The first total synthesis of anemarchalconyn and anemarcoumarin A. Journal of Asian Natural Products Research, 2017, 19(9): 903-909. (中科院四区)<br>
14. Ma, Wenbo; Tan, Yuqiang; Wang, Yang; Li, Zhiyi; Li, Zheyu; Gu, Linghui; Mei, Ruhuai; Cheng, An. Hydroxyl-Directed Ruthenium-Catalyzed peri-Selective C-H Acylmethylation and Annulation of Naphthols with Sulfoxonium Ylides. Organic Letters, 2021, 23(16): 6200-6205. (中科院二区,TOP期刊)<br>
15. Gu, Linghui; Wang, Yang; Cheng, Zemin; Sun, Yanan; Gong, Xin; Li, Zheyu; Ma, Wenbo*. Bronsted Acid Promoted N-Dealkylation of N-Alkyl(sulfon)amides. ChemistrySelect, 2021, 6(33): 8839-8842. (中科院四区)<br>
16. Dong, Hong-Bo*; Hou, Ming; Ma, Wen-Bo; Zhang, Jing-Xia; Li, Zhe-Yu; Luo, Hong-Bing; Tang, Ke-Hui; Cao, Sheng-Hua. First total synthesis of a new phenylpropanoid glycoside: natural cytotoxic compound from Cirsium japonicum. Journal of Asian Natural Products Research, 2018, 20(12): 1154-1161. (中科院四区)<br>
17. Weng, Zhengyun; Fang, Xinyue; He, Meicui; Gu, Linghui; Lin, Jiafu; Li, Zheyu; Ma, Wenbo*. Ruthenium Catalyzed C-H Selenylations of Aryl Acetic Amides and Esters via Weak Coordination. Organic Letters, 2019, 21(16): 6310-6314. (中科院二区,TOP期刊)<br>
教学科研成果 科科研项目:
1. 四川省科技计划项目,省部级,在研,主持;<br>
2. 四川省科技创新苗子工程资助项目,省部级,结题,主持;<br>
3. 四川省重点实验室开放课题项目,厅局级,结题,主持;<br>
4. 草榴社区 人才工程科研启动项目,结题,主持;<br>
5. 国家自然科学基金青年项目,国家级,结题,参与。<br>授权专利:<br>
授权专利:<br>
1. 一种以硫醇作为硫源的铜介导合成硫化吡咯和吲哚类化合物的方法,2023,中国专利CN117843612A<br>
2. 一种钌催化合成酰氧基化2-苯甲酰吡啶类化合物的方法,2023,中国专利CN117229200A<br>
3. 一种炔基膦酸盐电化学环化的方法,2023,中国专利CN117026251A<br>
4. 一种钯催化合成硒/硫化2-氨基联苯类化合物及构建含硒/硫八元环衍生物的方法,2023,中国专利CN116606264A<br>
5. 一种芳姜黄酮对黄曲霉作用机制的研究方法,2023,中国专利CN116042904A<br>
6. 一种合成爱德万甜中间体3-羟基-4-甲氧基苯丙醛的方法,2022,中国专利CN115403456A<br>
7. 一种头孢菌素类化合物及其制备方法和用途,2019,中国专利CN 106967093 B<br>
8. 一种对二氟烷基的芳基噁唑烷酮类化合物及其制备方法,2020,中国专利CN111808041A<br>
9. 一种钌催化N-芳基酰胺类化合物与碳酸亚乙烯脂合成吲哚类化合物的方法,2021,中国专利202111070628.5<br>
10. 一种钌催化制备萘并吡喃类化合物的方法,2021,中国专利CN113045530A<br>
11. 一种采用氨基柱测定福多司坦有关物质的方法,2015,中国专利CN 104931603 B<br>
12. 一种头孢替坦二钠中杂质的制备与结构确证方法,2015,中国专利CN 104910192 B<br>
13. 一种红霉素肟的制备纯化方法,2015,中国专利CN104788520A<br>
14. 一种二氢高红霉素的制备纯化方法,2015,中国专利CN104817600A<br>
15. 一种顶空气相色谱法测定头孢曲嗪中残留杂质丙二醇的方法,2016,中国专利ZL 201620028159.3<br>
16. 一种头孢唑肟钠中杂质的制备与结构确证方法,2016,中国专利CN 105646474 B <br>



1050C

李喆宇,博士研究生,副研究员。成都药学会会员、四川省食品安全检查专家、四川省药学职业技能大赛裁判。

学术经历:

本科:中国药科大学中药学

硕士:四川抗菌素工业研究所药物化学(分析)

博士:成都中医药大学草榴社区 中药化学(分析)

工作经历:

四川抗菌素工业研究所、草榴社区

基于质量控制的中药活性成分防霉养护技术研发与机制解析、过渡金属催化策略在抗菌药物研发中的应用与效能优化研究。

在国内外知名期刊上发表中英文论文38篇,其中中科院TOP期刊论文4篇、二区论文4篇。
1.Zheyu Li, Wenbo Ma, Linghui Gu, Jiayuan Xie, Kui Yang & Shibo Lin. Recent developments in the utilization of pyridones as privileged scaffolds in drug discovery, 20(7), 873–889. (中科院二区,一作)
2.Li B, Zhou Y, Xu Yue, Li Xiang, Li Zheyu, Gu Linghui, Ma Wenbo, Mei Ruhuai. Transition-Metal-Free Electrochemical Selenylative Cyclization of Alkynyl Phosphonates.The Journal of Organic Chemistry, 2023, 88(21):15414-15427. (中科院二区,通讯作者)
3.Jiajun Hu, Bo Li, Feng Xiong, Yue Xu, Zheyu Li, Linghui Gu. Electrochemically Driven Chalcogenative Cyclization of 2Alkynyl Aryl Oxime: Access to Functionalized Isoquinolines. The Journal of Organic Chemistry (中科院二区)
4.Li, B. , Zhou, Y. , Xu, Y. , Li, X. , Li, Z. , & Gu, L. , et al. (2023). Transition-metal-free electrochemical selenylative cyclization of alkynyl phosphonates. The Journal of Organic Chemistry, (21), 88. (中科院二区)
5.Tao Zheng, Zihan Yu, Junlong Li, Qilin Gu, Linghui Gu, Zheyu Li,* and Wenbo Ma*. Solvent-Free Dehydrogenative C-H Chalcogenations of Pyrazolones Using Mechanochemistry.Asian Journal Of Organic Chemistry,2024. (中科院四区,通讯作者)
6. Li, Zheyu#,*; Sun, Yanan#; Gu, Linghui; Wang, Yuchi; Xu, Mingqin; Zhou, Yunhao; Hu, Yichen*; Ma, Wenbo*. Ar-turmerone suppresses Aspergillus flavus growth and aflatoxin accumulation: Finding a new antifungal agent based on stored maize. Food Research International. 2023, 168: 112735. (中科院一区,TOP期刊,一作)
7. Gong, Xin; Yu, Na; Gu, Linghui; Li, Zheyu*; Ma, Wenbo*; Zhao, Fei*. Redox-neutral rhodium(iii)-catalyzed divergent synthesis of tetrasubstituted 1,3-enynes and alkynylated benzofurans. Organic & biomolecular chemistry, 2023, 21(1): 147-152. (中科院三区,通讯作者)
8. Li, Zheyu; Yang, Chen; Li, Zhiyi; Sun, Yanan; Lin, Shibo*; Hu, Yichen*. Application and safety evaluation of an anti-aflatoxigenic chitosan pouch containing turmeric essential oil in the storage of traditional Chinese health food. International Journal of Biological Macromolecules, 2021, 183(1): 1948-1958. (中科院二区,TOP期刊,一作)
9. Li, Zheyu; Lin, Shibo; An, Siyi; Liu, Lu; Hu, Yichen*; Wan, Li*. Preparation, characterization and anti-aflatoxigenic activity of chitosan packaging films incorporated with turmeric essential oil. International Journal of Biological Macromolecules, 2019, 131: 420-434. (中科院二区,TOP期刊,一作)
10. Lin Shibo, Liu Chun, Zhao Xiaotian, Han Xiao, Li Xuanhao, Ye Yongqin, Li Zheyu. Recent Advances of Pyridinone in Medicinal Chemistry. Frontiers in Chemistry. 2022, 10 (中科院三区)
11. Yu, Yao; Wang, Yang; Li, Bo; Tan, Yuqiang; Zhao, Huan; Li, Zheyu*; Zhang, Chunran*; Ma, Wenbo*. Ruthenium-Catalyzed Vinylene Carbonate Annulation by C-H/N-H Functionalizations: Step-Economical Access to Indoles. Advanced Synthesis & Catalysis, 2022, 364(4): 838-844. (中科院二区,通讯作者)
12. Liu, Changying#; Li, Zheyu#; Weng, Zhengyun; Fang, Xinyue; Zhao, Fei; Tang, Kehui*; Chen, Jianyang*; Ma, Wenbo*. Transition-Metal-Free Selective C(sp(3))-H Thiolation of Arylacetamides with Substituted Benzenethiols, Aryl Sulfenylchlorides and Diaryl Disulfides. Asian Journal of Organic Chemistry, 2020, 9(4): 668-672. (中科院三区,共同一作)
13. Zhang, Jing-Xia; Li, Zhe-Yu; Wang, Yu-Chi; Ma, Wen-Bo; Hou, Ming; Cao, Sheng-Hua; Tang, Ke-Hui; Dong, Hong-Bo*. The first total synthesis of anemarchalconyn and anemarcoumarin A. Journal of Asian Natural Products Research, 2017, 19(9): 903-909. (中科院四区)
14. Ma, Wenbo; Tan, Yuqiang; Wang, Yang; Li, Zhiyi; Li, Zheyu; Gu, Linghui; Mei, Ruhuai; Cheng, An. Hydroxyl-Directed Ruthenium-Catalyzed peri-Selective C-H Acylmethylation and Annulation of Naphthols with Sulfoxonium Ylides. Organic Letters, 2021, 23(16): 6200-6205. (中科院二区,TOP期刊)
15. Gu, Linghui; Wang, Yang; Cheng, Zemin; Sun, Yanan; Gong, Xin; Li, Zheyu; Ma, Wenbo*. Bronsted Acid Promoted N-Dealkylation of N-Alkyl(sulfon)amides. ChemistrySelect, 2021, 6(33): 8839-8842. (中科院四区)
16. Dong, Hong-Bo*; Hou, Ming; Ma, Wen-Bo; Zhang, Jing-Xia; Li, Zhe-Yu; Luo, Hong-Bing; Tang, Ke-Hui; Cao, Sheng-Hua. First total synthesis of a new phenylpropanoid glycoside: natural cytotoxic compound from Cirsium japonicum. Journal of Asian Natural Products Research, 2018, 20(12): 1154-1161. (中科院四区)
17. Weng, Zhengyun; Fang, Xinyue; He, Meicui; Gu, Linghui; Lin, Jiafu; Li, Zheyu; Ma, Wenbo*. Ruthenium Catalyzed C-H Selenylations of Aryl Acetic Amides and Esters via Weak Coordination. Organic Letters, 2019, 21(16): 6310-6314. (中科院二区,TOP期刊)

科科研项目: 1. 四川省科技计划项目,省部级,在研,主持;
2. 四川省科技创新苗子工程资助项目,省部级,结题,主持;
3. 四川省重点实验室开放课题项目,厅局级,结题,主持;
4. 草榴社区 人才工程科研启动项目,结题,主持;
5. 国家自然科学基金青年项目,国家级,结题,参与。
授权专利:
授权专利:
1. 一种以硫醇作为硫源的铜介导合成硫化吡咯和吲哚类化合物的方法,2023,中国专利CN117843612A
2. 一种钌催化合成酰氧基化2-苯甲酰吡啶类化合物的方法,2023,中国专利CN117229200A
3. 一种炔基膦酸盐电化学环化的方法,2023,中国专利CN117026251A
4. 一种钯催化合成硒/硫化2-氨基联苯类化合物及构建含硒/硫八元环衍生物的方法,2023,中国专利CN116606264A
5. 一种芳姜黄酮对黄曲霉作用机制的研究方法,2023,中国专利CN116042904A
6. 一种合成爱德万甜中间体3-羟基-4-甲氧基苯丙醛的方法,2022,中国专利CN115403456A
7. 一种头孢菌素类化合物及其制备方法和用途,2019,中国专利CN 106967093 B
8. 一种对二氟烷基的芳基噁唑烷酮类化合物及其制备方法,2020,中国专利CN111808041A
9. 一种钌催化N-芳基酰胺类化合物与碳酸亚乙烯脂合成吲哚类化合物的方法,2021,中国专利202111070628.5
10. 一种钌催化制备萘并吡喃类化合物的方法,2021,中国专利CN113045530A
11. 一种采用氨基柱测定福多司坦有关物质的方法,2015,中国专利CN 104931603 B
12. 一种头孢替坦二钠中杂质的制备与结构确证方法,2015,中国专利CN 104910192 B
13. 一种红霉素肟的制备纯化方法,2015,中国专利CN104788520A
14. 一种二氢高红霉素的制备纯化方法,2015,中国专利CN104817600A
15. 一种顶空气相色谱法测定头孢曲嗪中残留杂质丙二醇的方法,2016,中国专利ZL 201620028159.3
16. 一种头孢唑肟钠中杂质的制备与结构确证方法,2016,中国专利CN 105646474 B