草榴社区

以基因组挖掘为手段发现新型抗感染活性天然分子； 解析微生物及植物源复杂天然分子的生物合成途径及关键酶催化机制； 融合生物合成与化学合成创制结构多样的“非天然”多肽分子； 运用合成生物学等手段提升高价值分子在底盘细胞中的产量。

1. Xin, He; Jinqiu, Ren; Li, Wang; Jianying, Luo; Jing, Yang; Yu-Cheng, Gu; Yijun, Yan; Sheng-Xiong, Huang. Discovery and Biosynthetic Origin of Quinolizidomycins A and B, Two Quinolizidine Alkaloids from Streptomyces sp. KIB-1714. Organic Letters, 2023, 25(10), 1760–1764.
2. Xin, He; Guoqing, Peng; Jianying, Luo; Jian-Ping, Huang; Jing, Yang; Yijun Yan; Yucheng, Gu; Li, Wang; Sheng-Xiong, Huang. O-Alkylazoxymycins A–F, Naturally Occurring Azoxy-Aromatic Compounds from Streptomyces sp. Py50. Journal of Natural Products, 2023, 86(1), 176–181.
3. Xin, He; Yong-jiang, Wang; Rong-Hua, Luo; Liu-Meng, Yang; Li, Wang; Dale, Guo; Jing, Yang; Yun, Deng; Yong-Tang, Zheng; Sheng-Xiong, Huang. Dimeric pyranonaphthoquinone glycosides with anti-HIV and cytotoxic activities from a soil-derived Streptomyces. Journal of natural products, 2019, 82(7): 1813–1819.
4. Xin, He; Jing, Yan; Ling, Qiu; Dan, Feng; Feng, Ju; Lu, Tan; Yu-Zhi, Li; Yu-Cheng, Gu; Zhen, Zhang; Da-Le, Guo; Yun, Deng. Thiodiketopiperazines produced by Penicillium crustosum and their activities to promote gastrointestinal motility. Molecules, 2019, 24, 299.
5. Wang Yong-Jiang; Wang Li; He Xin; Xu Dong-Dong; Tang Jun; Ma Ya-Tuan; Yan Yi-Jun; Gu YuCheng; Yang Jing; Huang Sheng-Xiong; Characterization of inthomycin biosynthetic gene cluster revealing new insights into carboxamide formation, Chinese Journal of Natural Medicines, 2020, 18(9): 677-683.

纵向：
1. 国家自然科学基金青年基金项目，2026/01-2028/12，主持