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利用冷冻电镜技术解析细菌、病毒及哺乳动物系统中的致病性非编码RNA及其复合物的三维结构，揭示其功能机制，并基于结构进行针对这些RNA的小分子药物开发。

文章：
1.Jia X#, Pan Z#, Yuan Y#, et al. Structural basis of sRNA RsmZ regulation of Pseudomonas aeruginosa virulence. Cell Res. 2023;33(4):328-330. #共同第一作者 潘志凌, 贾新宇, 苏昭铭. 冷冻电镜研究RNA结构的进展. 中国科学: 生命科学. 2024;54:1424-1438.
2.Fu H, Liang Y, Zhong X, Pan Z, et al. Codon optimization with deep learning to enhance protein expression. Sci Rep. 2020;10(1):17617.
3.Pan S, Zhang L, Luo X, Nan J, Yang W, Bin H, Li Y, Huang Q, Wang T, Pan Z, et al. Structural Optimization and Structure-Activity Relationship Studies of 6,6-Dimethyl-4-(phenylamino)-6H-pyrimido[5,4-b][1,4]oxazin-7(8H)-one Derivatives as A New Class of Potent Inhibitors of Pan-Trk and Their Drug-Resistant Mutants. J Med Chem. 2022;65(3):2035-2058.
4.Jiao Y, Nan J, Mu B, Zhang Y, Zhou N, Yang S, Zhang S, Lin W, Wang F, Xia A, Cao Z, Chen P, Pan Z, et al. Discovery of a novel and potent inhibitor with differential species-specific effects against NLRP3 and AIM2 inflammasome-dependent pyroptosis. Eur J Med Chem. 2022;232:114194.